Topical agents are widely used to treat skin conditions, with the occurrence of bacterial resistance to antibiotics and controversy regarding the use of topical antiseptics persists, man turned to his prehistory and found literally thousands of phytochemicals, which inhibit different types of microorganisms. The specific aim of the present article was to prepare and evaluate antimicrobial herbal gel. The first step was the selection of plant parts according to long history of use, references in Ayurvedic literature, leaves extracts of Nyctanthes arbor-tristis. Plant materials were dried in the dark at room temperature. Ethanol was used as solvent for extraction by maceration procedure. These extracts were subjected to antimicrobial activity by agar diffusion method to detect potential antimicrobial activity against P. aeruginosa, E. coli and Bacillus substilis, some common human skin infecting pathogens. The results showed that ethanolic extracts of Nyctanthes arbor-tristis leaves posses strong in-vitro antibacterial activity. Each formulation was characterized in terms of viscosity, pH, extrudability, spreadability, homogenicity, antimicrobial activity compared with that of standard formulation. Among all the prepared formulations F2, F4 were regarded as the best formulations.
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